Micafungin (FK463), alone or in combination with other systemic antifungal agents, for the treatment of acute invasive aspergillosis
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چکیده
منابع مشابه
Micafungin (FK463), alone or in combination with other systemic antifungal agents, for the treatment of acute invasive aspergillosis.
BACKGROUND Micafungin (FK463) is a new lipopeptide compound (echinocandin) with activity against Aspergillus and Candida species. This study evaluated the safety and efficacy of micafungin in patients with proven or probable invasive aspergillosis (IA). METHODS A multinational, non-comparative study was conducted to examine proven or probable (pulmonary only) Aspergillus species infection in ...
متن کاملComparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits.
Micafungin (FK463) is an echinocandin that demonstrates potent in vitro antifungal activities against Candida and Aspergillus species. However, little is known about its comparative antifungal activities in persistently neutropenic hosts. We therefore investigated the plasma micafungin pharmacokinetics and antifungal activities of micafungin against experimental disseminated candidiasis and inv...
متن کاملMicafungin in the treatment of invasive candidiasis and invasive aspergillosis
Micafungin is an echinocandin antifungal agent available for clinical use in Japan, Europe, and the United States. Through inhibition of β-1,3-glucan production, an essential component of the fungal cell wall, micafungin exhibits potent antifungal activity against key pathogenic fungi, including Candida and Aspergillus species, while contributing minimal toxicity to mammalian cells. This activi...
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To cite: Abdulaziz S, Al Jahdali H, Baharoon S. BMJ Case Reports Published online: doi:10.1136/bcr-2012007824 DESCRIPTION A 58-year-old man with a history of AIDS and recurrent non-Hodgkin’s lymphoma had 1-week complaint of fever, productive cough and chest pain 2 weeks after chemotherapy. He was on antiretroviral triple therapy and antibiotics, but with no response. Physical examination was si...
متن کاملNewer combination antifungal therapies for invasive aspergillosis.
Optimal therapy for invasive aspergillosis is unknown, and many clinicians have attempted to utilize a combination antifungal approach to improve outcomes. However, while numerous in vitro studies, animal models, and clinical reports suggest the possibility that combination antifungal therapy might offer improved results, there is no definitive accepted strategy. The currently available antifun...
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ژورنال
عنوان ژورنال: Journal of Infection
سال: 2006
ISSN: 0163-4453
DOI: 10.1016/j.jinf.2006.03.003